Just having Joss Whedon involved instantly gives it more potential than something like shitty old Heroes which my sister and I used to watch as an accidental comedy because it was just so bad and totally insignificant that it was actually funny. Joss Whedon has a proven track record on TV, e.g., Firefly, Buffy, Angel, and Dollhouse, all of which had merits. Go ahead and judge, but my hope is that AoS is eventually at the same level that Buffy was at its peak . Although maybe that's a false hope.
As far as the pilot went, It wasn't very memorable, if you want my honest opinion. But I suppose there's only so much you can do with an introductory episode. This episode kind of reminded me of Bones, a little. And yet with a squeaky clean Disney superheroes veneer. I'm not saying that this necessarily is a bad thing, just that I hope the "procedural" elements & the child-friendly presentation doesn't prevent them from being original and not being afraid to go there.
I have to say, the characters are visually pretty forgettable people, but that said I think their characterizations have potential nevertheless. I'm going to go ahead and assume that Coulson is some kind of clone? So that story-arc has potential. As does Grant Ward's "porcupine syndrome".