Are you talking about the script extender? It uses a separate .exe instead of modifying the original one, so I'm not sure if Denuvo will actually affect it at all. No way to test out. Ultimately though, it will be up to the devs to ensure their game remains moddable if they choose to use Denuvo.
I think it may be something that only time will tell. I would differentiate jailbreaking and general cracking differently. The former comes with it a certain degree of challenge and repute, while the latter can become very monotonous when the process is dreary and time-consuming. The latter is effectively a job, and is very different from what cracking groups these days generally have to overcome.
Currently, leading cracking groups tend to only deal in high quantity of easy releases, and there is only about 3-4 of them (including 3DM). The non-Chinese groups of the lot tend to get replaced from time to time, e.g. Razor gets replaced by Skidrow. On the other hand, the vast majority of so-called cracking groups actually do nothing more than repackaging existing releases - a single scene release could result in 5-10 different repacks. And ever since Denuvo's first introduction, 3DM has been the only group even willing to tackle Denuvo.
Looking at a game like Lords of the Fallen (admittedly, not popular), it remained uncracked (as a low priority) for many many months, until 3DM was done with other Denuvo titles and returned to it. I too find it unimaginable that no other group out there even attempted the task while 3DM was busy elsewhere, but that's what happened.